Protective Effect Of Hydro-Ethanolic Extract Of Bushweed Flueggea Virosa On Renal Damage In Streptozotocin-Induced Hyperglycemia In Rat

Aim: To study the effect of hydro-ethanolic extract Flueggea virosa on Streptozotocin-induced hyperglycemia in rats with respect to kidney function parameters and histology.
 Methods: 
 Daily single oral doses (100 200 mg/kg) anti-diabetic drug Metformin (500 were administered for 21 days three groups rendered diabetic by a injection Streptozotocin (60mg/kg). The body weight blood glucose levels recorded every 7th day. On 21st day, euthanized collected testing functions.
 Results: Treatment metformin significantly reduced fasting levels, urea, creatinine, uric acid, urea nitrogen increased total protein. Histological studies showed retard onset glomerular hypertrophy, mesangial expansion, tubular dilation, collagen fiber deposition inflammatory cells accumulation. Thus indicated delayed progression nephropathy. Conclusion: Rats Streptozotocin, (200 metformin. These treatments